Necrotizing fasciitis is a necrotizing soft tissue infection that can result in fast tissue loss, necrosis, and potentially fatal acute sepsis. Diabetes, cancer, alcohol abuse, and chronic liver and renal disease are all risk factors for necrotizing fasciitis.<\/p>\n
Clinical presentation<\/strong>:<\/h2>\nA 70-year-old female was admitted with complaints of chronic right leg pain and swelling. She was a known diabetic, obese and non- ambulant. There was no prior history of trauma. Initially it was treated as cellulitis of the right calf but during admission, the swelling was seen ascending to the thigh with tenderness. Patient was subjected to duplex to rule out deep vein thrombosis, incidentally, multiple echogenic foci with dirty shadowing was noted in the subcutaneous plane in the thigh, obscuring the underlying structures. Patient was then subjected to CT and MRI.<\/p>\n
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<\/em><\/strong><\/p>\nImaging findings<\/em><\/strong>: CT abdomen sagittal and coronal views shows multiple air pockets in the subcutaneous as well as intramuscular plane in the right thigh and gluteal region. The air pockets are seen extending via the psoas and the paraspinal muscles to the other retroperitoneal spaces.<\/p>\n![\"\"](\"https:\/\/www.kauveryhospital.com\/ima-journal\/wp-content\/uploads\/2024\/04\/img-2-192x300.jpg\")
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Imaging findings<\/em><\/strong>: Radiograph of \u00a0right knee shows multiple radiolucenies seen in the subcutaneous and deep muscular plane. There is displaced fracture of the proximal shaft of tibia.<\/p>\n![\"\"](\"https:\/\/www.kauveryhospital.com\/ima-journal\/wp-content\/uploads\/2024\/04\/img-3.jpg\")
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Imaging findings:<\/em><\/strong> Diffuse STIR hyper intensities with multiple hypointensities- suggestive of air pockets noted in the subcutaneous as well as intra\/intermuscular plane in the gluteal region as well as thigh (predominantly anterior) extending upto the knee.<\/p>\nDiscussion:<\/strong><\/h2>\nNecrotizing fasciitis is a fast-spreading and frequently fatal soft tissue infection that typically arises due to a polymicrobial infection. The infection starts in the superficial fascial planes and subsequently advances into the deep fascial layers, leading to necrosis through microvascular occlusion. The infectious agents responsible for this condition are typically a combination of aerobic and anaerobic organisms, including Clostridium species, Proteus species, Escherichia coli, Bacteroides species, Enterobactericeae species, and others. Necrotizing fasciitis is a medical emergency with a high mortality rate of 70-80%, with common causes of death being sepsis or respiratory, renal, or multisystem organ failure.<\/p>\n
The Society of Infectious Disease categorizes necrotizing fasciitis into two types based on bacteriology profile: Type I and Type II<\/em>. Type I is characterized by a mixed infection with both aerobic and anaerobic bacteria, and is frequently observed in patients with underlying medical conditions such as diabetes mellitus, peripheral vascular disease, alcoholism, malignancy (particularly leukaemia and lymphoma), immunocompromised, and post-surgical status (especially transplantations). Fournier gangrene, which refers to necrotizing fasciitis of the perineum, typically falls under Type I. On the other hand, Type II necrotizing fasciitis is caused by either group A Streptococcus (GAS, S. pyogenes) or Staphylococcus aureus, leading to gangrenous myofascitis with the potential complication of toxic shock syndrome, primarily due to the release of exotoxins A, B, and C. A crucial molecular virulent factor in GAS organisms is M-protein, which has antiphagocytic properties that enable the bacteria to evade the immune system’s defenses.<\/p>\nClinical findings of necrotizing fasciitis include patchy skin discoloration, severe pain, and ill-defined swelling. Imaging, such as MRI, CT, and ultrasound, plays a crucial role in confirming the diagnosis and assessing the extent of the infection. Gas within the necrotized fasciae is a characteristic finding, but it may not always be present. Early diagnosis and aggressive surgical treatment are essential to reduce mortality, as the condition can be fatal if not promptly recognized and treated. Imaging findings, such as asymmetric thickening of fascia, soft tissue air, and blurring of fascial planes, help differentiate necrotizing fasciitis from other soft-tissue infections. The presence of soft-tissue gas, although specific, is not always present in all cases. Understanding the clinical and imaging features of necrotizing fasciitis is crucial for accurate and timely intervention to improve patient outcomes.<\/p>\n
<\/em><\/strong><\/p>\nImaging findings<\/em><\/strong>: CT abdomen sagittal and coronal views shows multiple air pockets in the subcutaneous as well as intramuscular plane in the right thigh and gluteal region. The air pockets are seen extending via the psoas and the paraspinal muscles to the other retroperitoneal spaces.<\/p>\n Imaging findings<\/em><\/strong>: Radiograph of \u00a0right knee shows multiple radiolucenies seen in the subcutaneous and deep muscular plane. There is displaced fracture of the proximal shaft of tibia.<\/p>\n Imaging findings:<\/em><\/strong> Diffuse STIR hyper intensities with multiple hypointensities- suggestive of air pockets noted in the subcutaneous as well as intra\/intermuscular plane in the gluteal region as well as thigh (predominantly anterior) extending upto the knee.<\/p>\n Necrotizing fasciitis is a fast-spreading and frequently fatal soft tissue infection that typically arises due to a polymicrobial infection. The infection starts in the superficial fascial planes and subsequently advances into the deep fascial layers, leading to necrosis through microvascular occlusion. The infectious agents responsible for this condition are typically a combination of aerobic and anaerobic organisms, including Clostridium species, Proteus species, Escherichia coli, Bacteroides species, Enterobactericeae species, and others. Necrotizing fasciitis is a medical emergency with a high mortality rate of 70-80%, with common causes of death being sepsis or respiratory, renal, or multisystem organ failure.<\/p>\n The Society of Infectious Disease categorizes necrotizing fasciitis into two types based on bacteriology profile: Type I and Type II<\/em>. Type I is characterized by a mixed infection with both aerobic and anaerobic bacteria, and is frequently observed in patients with underlying medical conditions such as diabetes mellitus, peripheral vascular disease, alcoholism, malignancy (particularly leukaemia and lymphoma), immunocompromised, and post-surgical status (especially transplantations). Fournier gangrene, which refers to necrotizing fasciitis of the perineum, typically falls under Type I. On the other hand, Type II necrotizing fasciitis is caused by either group A Streptococcus (GAS, S. pyogenes) or Staphylococcus aureus, leading to gangrenous myofascitis with the potential complication of toxic shock syndrome, primarily due to the release of exotoxins A, B, and C. A crucial molecular virulent factor in GAS organisms is M-protein, which has antiphagocytic properties that enable the bacteria to evade the immune system’s defenses.<\/p>\n Clinical findings of necrotizing fasciitis include patchy skin discoloration, severe pain, and ill-defined swelling. Imaging, such as MRI, CT, and ultrasound, plays a crucial role in confirming the diagnosis and assessing the extent of the infection. Gas within the necrotized fasciae is a characteristic finding, but it may not always be present. Early diagnosis and aggressive surgical treatment are essential to reduce mortality, as the condition can be fatal if not promptly recognized and treated. Imaging findings, such as asymmetric thickening of fascia, soft tissue air, and blurring of fascial planes, help differentiate necrotizing fasciitis from other soft-tissue infections. The presence of soft-tissue gas, although specific, is not always present in all cases. Understanding the clinical and imaging features of necrotizing fasciitis is crucial for accurate and timely intervention to improve patient outcomes.<\/p>\n<\/p>\n<\/p>\nDiscussion:<\/strong><\/h2>\n
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Dr. Babu Peter Sathyanathan<\/strong>![\"\"](\"https:\/\/www.kauveryhospital.com\/ima-journal\/wp-content\/uploads\/2024\/04\/rupinii-150x150.jpg\")
Dr. Rupini.S<\/strong>![\"\"](\"https:\/\/www.kauveryhospital.com\/ima-journal\/wp-content\/uploads\/2024\/04\/Dr.Deepan-150x150.jpg\")
Dr. Deepan<\/strong>