Preparing your manuscript

Dr. Prabhaharan Renganathan, Technical Editor, Kauvery Hospitals

Case Report

Kauverian e-Medical Journal invites briefly described case reports that include the following criteria:

  • Unusual side effects or adverse interactions involving medications.
  • Unexpected or unusual presentations of a disease.
  • New associations or variations in disease processes.
  • Presentations, diagnoses and management of new and emerging diseases.
  • Unexpected association between diseases or symptoms.
  • Unexpected event in the course of observing or treating a patient.

The information below details the section headings that you should include in your manuscript and what information should be within each section.

Preparing main manuscript text

Quick points

  • Use double line spacing
  • Include line and page numbering
  • Use SI units: Please ensure that all special characters used are embedded in the text, otherwise they will be lost during conversion to PDF
  • Do not use page breaks in your manuscript

File formats

The following word processor file formats are acceptable for the main manuscript document:

  • Microsoft word (DOC, DOCX),
  • Rich text format (RTF).

The information below details the section headings that you should include in your manuscript and what information should be within each section.

Title page

Title: The title page should present a title that includes, the study design.

Affiliations and correspondence: List the full names and institutional addresses for all authors and indicate the corresponding author information including email address and/or telephone number.

Article Title

Al: Firstname Surname*, A2: Firstname Surname

Department of XXXXXXXX, Kauvery Hospitals, India

*Correspondence: Tel.: +91 xxxxx xxxxx; email:


The abstract should not exceed 350 words. Please minimize the use of abbreviations and do not cite references in the abstract. The abstract must include the following separate sections:

Background: why the case should be reported and its novelty

Case presentation: a brief description of the patient’s clinical and demographic details, the diagnosis, any interventions and the outcomes

Conclusions: a brief summary of the clinical impact or potential implications of the case report

Keywords: Three to ten keywords representing the main content of the article.


Background: Multiple sclerosis is a disease with remitting and relapsing course and the normal classification is more based on the clinical manifestation and MRI scan findings. There are rare types of multiple sclerosis where demyelination can be monophasic orpolyphask.

Case presentation: We present a patient with tumefactive multiple sclerosis (TMS) with a typical relapsing and remitting course initially but later exhibited secondary progression.

Conclusion: TMS presents like a space occupying lesion or tumour so it is important to make the correct diagnosis, sometimes requiring a biopsy for confirmation. Treatment choice is tough but needs to be commenced early for better control and outcome. This patient deferred disease modifying agents for a long time but when she finally accepted treatment, it was too late as she developed secondary progression with a relentless course.

Keywords: Multiple sclerosis, Tumefactive MS


The background section should explain the background to the case report or study, its aims, a summary of the existing literature.

Case presentation

This section should include a description of the patient’s relevant demographic details, medical history, symptoms and signs, treatment or intervention, outcomes and any other significant details.

Discussion and Conclusions

This should discuss the relevant existing literature and should state clearly the main conclusions, including an explanation of their relevance or importance to the field.


Multiple sclerosis (MS), an inflammatory and ‘disseminated in time’, appearing episodically over time [1-3].

Case Presentation

A 48-year-old female with…… (Figs. 1 and 2). MRS showed elevated choline and lipid lactates and reduction in NAA and Cr. The differentials included glioma/astrocytoma.


Tumefactive MS (TMS) is very rare with an incidence Thus this drug is to be considered with caution for long-term treatment [11-14].


TMS presents like a space occupying lesion as she developed secondary progression with a relentless course.

List of abbreviations

If abbreviations are used in the text they should be defined in the text at first use, and a list of abbreviations should be provided.


Multiple sclerosis (MS), an inflammatory condition causes demyelination and axonal loss in the central nervous system (brain and spinal cord). The primary brain insult ‘(sclerosis)’ and its clinical sequelae are ‘disseminated in space’, affecting different anatomical sites, and ‘disseminated in time’, appearing episodically over time [1-3].

The sub-division of MS as relapsing and remitting type (RRMS), secondary progressive MS (SPMS) and primary progressive MS (PPMS) is based more on clinical characteristics and not specific biologic pathophysiology. Nonetheless, they provide an organized framework for diagnosis and long-term management.


Please acknowledge anyone who contributed towards the article who does not meet the criteria for authorship including anyone who provided professional writing services or materials.

Authors’ contributions

The individual contributions of authors to the manuscript should be specified in this section.

Competing interests

All financial and non-financial competing interests must be declared in this section.


Thankful to Department of XXXXXXX, Kauvery Hospitals, India.

Competing interests

The authors have no competing interest to declare.

Author contributions

Supervised by XXXXXXXX. Patient was under the care of XXXXXXXXXX. Report written by XXXXXX and edited by XXXXXXXXXXXXX.


Examples of the Vancouver reference style are shown below.

  • Article – Slifka MK, Whitton JL. Clinical implications of dysregulated cytokine production. Am J Sci. 1999;36:234-5.
  • Article within a journal by DOI – Slifka MK, Whitton JL. Clinical implications of dysregulated cytokine production. Dig J Mol Med. 2000; doi:10.1007/s801090000086.
  • Article with no page numbers – Slifka MK, Whitton JL. Clinical implications of dysregulated cytokine production. Am J Sci. 1999;36:234-5.
  • Book chapter – Wyllie AH, Kerr JFR, Currie AR. Cell death: the significance of apoptosis. In: Bourne GH, Danielli JF, Jeon KW, editors. International review of cytology. London: Academic; 1980. p. 251-306.
  • Complete book, authored – Blenkinsopp A, Paxton P. Symptoms in the pharmacy: a guide to the management of common illness. 3rd ed. Oxford: Blackwell Science; 1998.
  • Online document – Doe J. Title of subordinate document. In: The dictionary of substances and their effects. Royal Society of Chemistry. 1999. of subordinate document. Accessed 15 Jan 1999.
  • Online database – Healthwise Knowledgebase. US Pharmacopeia, Rockville. 1998. Accessed 21 Sept 1998.

Preparing figures

  1. When preparing figures, please follow the formatting instructions below.
  2. Figures should be numbered in the order they are first mentioned in the text, and uploaded in this order. Multi-panel figures (those with parts a, b, c, d etc.) should be submitted as a single composite file that contains all parts of the figure.
  3. Figures should be uploaded in the correct orientation.
  4. Figure titles (max 15 words) and legends (max 300 words) should be provided in the main manuscript, not in the graphic file.
  5. Figure keys should be incorporated into the graphic, not into the legend of the figure.
  6. Each figure should be closely cropped to minimize the amount of white space surrounding the illustration. Cropping figures improves accuracy when placing the figure in combination with other elements when the accepted manuscript is prepared for publication on our site. For more information on individual figure file formats, see our detailed instructions.
  7. Individual figure files should not exceed 10 MB. If a suitable format is chosen, this file size is adequate for extremely high quality figures.

Figure file types

We accept the following file formats for figures:

  1. PDF (suitable for diagrams and/or images)
  2. Microsoft Word (suitable for diagrams and/or images, figures must be a single page)
  3. PowerPoint (suitable for diagrams and/or images, figures must be a single page)
  4. TIFF (suitable for images)
  5. JPEG (suitable for photographic images, less suitable for graphical images)
  6. PNG (suitable for images)

Figure size and resolution

  1. width of 85 mm for half page width figure
  2. width of 170 mm for full page width figure
  3. maximum height of 225 mm for figure and legend
  4. image resolution of approximately 300 dpi (dots per inch) at the final size