Recommended Readings

(1). Anthony S. Fauci. It Ain’t Over Till It’s Over…but It’s Never Over – Emerging and Reemerging Infectious Diseases. 2022.

(2). Annette M. Esper, et al. Systematized and efficient: organization of critical care in the future. Crit Care. 2022; 26: 366.

Since the advent of critical care in the twentieth century, the core elements that are the foundation for critical care systems, namely to care for critically ill and injured patients and to save lives, have evolved enormously. The past half-century has seen dramatic advancements in diagnostic, organ support, and treatment modalities in critical care, with further improvements now needed to achieve personalized critical care of the highest quality. For critical care to be even higher quality in the future, advancements in the following areas are key: the physical ICU space; the people that care for critically ill patients; the equipment and technologies; the information systems and data; and the research systems that impact critically ill patients and families. With acutely and critically ill patients and their families as the absolute focal point, advancements across these areas will hopefully transform care and outcomes over the coming years.

(3). James D. Douketis, et al. Perioperative Management of Antithrombotic Therapy. Chest. 2012 Feb; 141(2 Suppl): e326S-e350S.

In patients requiring vitamin K antagonist (VKA) interruption before surgery, we recommend stopping VKAs 5 days before surgery instead of a shorter time before surgery (Grade 1B). In patients with a mechanical heart valve, atrial fibrillation, or VTE at high risk for thromboembolism, we suggest bridging anticoagulation instead of no bridging during VKA interruption (Grade 2C); in patients at low risk, we suggest no bridging instead of bridging (Grade 2C). In patients who require a dental procedure, we suggest continuing VKAs with an oral prohemostatic agent or stopping VKAs 2 to 3 days before the procedure instead of alternative strategies (Grade 2C). In moderate- to high-risk patients who are receiving acetylsalicylic acid (ASA) and require noncardiac surgery, we suggest continuing ASA around the time of surgery instead of stopping ASA 7 to 10 days before surgery (Grade 2C). In patients with a coronary stent who require surgery, we recommend deferring surgery > 6 weeks after bare-metal stent placement and > 6 months after drug-eluting stent placement instead of undertaking surgery within these time periods (Grade 1C); in patients requiring surgery within 6 weeks of bare-metal stent placement or within 6 months of drug-eluting stent placement, we suggest continuing antiplatelet therapy perioperatively instead of stopping therapy 7 to 10 days before surgery (Grade 2C).

(4). Aleksandra Leligdowicz, et al. Immune Modulation in Sepsis, ARDS, and Covid-19 – The Road Traveled and the Road Ahead. NEJM Evid. 2022;1(11).

Leligdowicz et al. consider the history and future of immunomodulating therapies in sepsis and ARDS, including ARDS due to Covid-19, and remark on the larger challenge of clinical research on therapies for syndromes with profound clinical and biologic heterogeneity.

(5). Stephen M. Carpenter, et al. How Do I Navigate Latent Tuberculosis Diagnosis? How Do I Navigate Latent Tuberculosis Diagnosis? NEJM Evid 2022; 1 (11).

Tuberculosis (TB) is one of the most common infectious causes of death in the world. Classically, latent TB infection is understood as a state of quiescent, clinically asymptomatic, noncontagious, chronic infection with the bacterial pathogen Mycobacterium tuberculosis that may persist for many years. Diagnosis of latent TB infection is clouded by areas of uncertainty intrinsic to diagnostic tests and the heterogeneity in how TB manifests across individuals. This Curbside Consult explores the common question: How do I navigate latent tuberculosis diagnosis?

(6). Sue Nelson. Autism: Understanding my childhood habits. 2022.

How do children with autism experience the world? And how could we use this understanding to help children fulfil their potential, form friendships, and enjoy life?

We look to scientific research for answers – and there is a growing body of evidence providing fascinating new insights into behaviours that were long considered a mystery.

Autism Spectrum Disorder, or autism, affects one in every 100 children, according to the World Health Organization. A developmental condition caused by differences in the brain, it can affect how a person absorbs, processes and responds to information. It is usually categorised along a spectrum, from mild to severe. In the Diagnostic and Statistical Manual of Mental Disorders (DSM 5), published by the American Psychiatric Association, this spectrum is divided into levels 1, 2 and 3, where those with level 3 autism require “very substantial support”. Within those categories, there is a huge diversity of needs and experiences, as well as some common traits.

(7). Anne L. Peters. New Studies Change Beliefs About Cardiovascular Disease. 2022.

(8). Steven Lome. Half Marathon Heart Crisis — Times Two. 2022.

(9). Chao Jiang, et al. Effects of Intensive Blood Pressure Control on Cardiovascular and Cognitive Outcomes in Patients With Atrial Fibrillation

(10). Richard Mark Kirkner. ACR, EULAR Roll Out Updated Antiphospholipid Syndrome Criteria. 2022.

(11). Kate Johnson. Most Global Bacterial Deaths in 2019 Linked to Five Pathogens. 2022

(12). Shirlene Obuobi. Why it seems like your doctor doesn’t care about you. 2022. system/

(13). Just 10 Minutes of Walking a Day Can Lead to Longer Lives

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