All about Kawasaki Disease in Children

All about Kawasaki Disease in Children
July 01 11:13 2025 Print This Article

Summary

Kawasaki Disease is a rare kind of vascular condition that affects children in the age-group of 6 months to 5 years. However, it can be found in older children too. If detected late or not treated on time, it can lead to various complications, including death. In recent decades, treatment options for Kawasaki Disease have improved, so the outlook towards the condition is positive. In this article, we will know more about the condition.

Introduction

Vasculitis is a condition in which, some blood-vessels in the body get inflamed for one or more reasons. This affects blood-flow to that part of the body, which in-turn affects the health of organs, glands and tissues in that region. There are nearly 20 different disorders grouped under Vasculitis. They are classified based on size of blood-vessels affected – whether the condition affects large blood-vessels, mid-sized ones, smaller vessels, variable vessels, or others.

According to paediatricians, one such, rare type of Vasculitis is ‘mucocutaneous lymph-node syndrome’. Instances of this disease have been documented in medical journals, as early as 1871. In 1967, Japanese paediatrician Tomisaku Kawasaki described 50 cases of the disease in children, in detail. That’s when the disease was begun to be noticed and taken seriously. In his honour, the condition is named Kawasaki Disease.

In this condition, the blood-vessels get inflamed. This weakens the walls of the blood-vessels. They get stretched out and become thin. As a result, blood-flow reduces. The condition affects children in the age-group of 6 months to 5 years. It can affect any artery or set of arteries in the body. However, most often, it affects the coronary arteries of the heart. This impacts the normal functioning of the heart resulting in heart-issues and other symptoms.

Causes and Risk Factors 

Kawasaki Disease (KD) is an idiopathic condition. That is, the cause is not clearly known. Unknown viruses, bacteria, parasites and environmental-toxins have been attributed to as causes. However, there is not enough evidence for the same. Since the reason is unknown, it is difficult to prevent KD. However, there are some risk factors for KD.

  • Age: Children under 5 years old are at higher risk. Older children and adults are rarely known to develop this condition.
  • Gender: Boys are more at risk than girls
  • Ethnicity and Race: Children of Asian, Pacific Islander and African Black descent have higher rates of Kawasaki disease than white Caucasians.

However, please note, one may not fit into any of the above 3 risk factors but can still develop KD.

Symptoms of Kawasaki Disease (KD) 

  • Irritability
  • Pain in the joints
  • Vomiting and nausea
  • High fever of 101 F and above, that lasts for more than 5 days, and doesn’t go away in spite of medication
  • Red rashes on chest, legs, genitals and groin area
  • Skin on the fingers and toes starts to peel off, generally happens in 2-3 weeks from start of the condition
  • Swelling in the hands and bottom of feet
  • Reddish eyes
  • Swollen lymph glands/nodes, especially in the neck
  • Inflamed, red and dry lips, insides of the mouth and throat
  • Light coloured tongue with bright red spots (called “strawberry tongue”)
  • Rapid heart rate

In later stages, the child may show the following symptoms:

  • Pain in the abdomen
  • Vomiting and nausea
  • Diarrhoea
  • Enlarged gallbladder
  • Temporary hearing loss

Complications from Kawasaki Disease (KD) 

  • Weakening of one of the heart’s arteries leading to an aneurysm there, condition called as coronary artery aneurysm. This may require a coronary bypass surgery
  • The above condition can also lead to coronary artery rupture
  • Dysrhythmia or unusual heart rhythms
  • Inflammation of the covering of the heart (pericarditis), lining of the heart (endocarditis) and heart muscle (myocarditis)
  • Damaged heart valves leading to mitral valve regurgitation
  • Heart muscle that doesn’t work well leading to heart attack
  • Heart failure
  • Blood clots inside (thrombosis), and narrowing (stenosis) of – coronary arteries
  • Hepatitis in the child’s liver
  • Inflammation in the child’s lungs
  • Inflammation in the child’s pancreas (pancreatitis)

Diagnosis 

  • Blood tests: This helps rule out other diseases with similar symptoms, and also check blood cell count. A high WBC count, low RBC count (anaemia) and inflammation are all signs of KD.
  • Urinalysis: this will show any signs of infection and inflammation
  • Echocardiogram: This helps view the child’s heart and arteries
  • Electrocardiogram (EKG): This measures the rhythm in the child’s heart
  • CT (computed tomography) angiogram that uses X-rays and a computer
  • MRA (magnetic resonance angiogram) that uses an MRI machine

At this juncture, it’s important to note that most of the symptoms of KD are not unique and are similar to that of other ailments. That’s why, the above diagnostic tests are not primarily aimed at confirming KD, but rather ruling out conditions with similar symptoms, such as:

  • Scarlet fever
  • Medication side-effects
  • Juvenile rheumatoid arthritis
  • Toxic shock syndrome
  • Idiopathic juvenile arthritis
  • Stevens-Johnson syndrome, a disorder that affects mucous membranes
  • Juvenile mercury poisoning
  • Measles
  • Rocky Mountain spotted fever; an illness caused by ticks

Treatment for Kawasaki Disease (KD) 

Treatment options are many and are all aimed at preventing or minimizing damage to coronary arteries, reducing inflammation, preventing blood-clots and heart complications. They include:

  • Intravenous Immunoglobulin (IVIG): Immunoglobulins are human blood-proteins that are given to the child via IV injections. In most cases, one dose is good enough, however some children will need a second dose, as well as other medication.
  • Aspirin: this is given in a controlled fashion to minimize side-effects
  • Hydrating fluids by IV
  • Medications for swelling and pain
  • Anticoagulants: These are blood-thinners and are given when the child is at a risk of developing blood-clots
  • Steroids or NSAIDS – both of which help reduce inflammation in the body. NSAIDS are given when the inflammation is mild, and steroids when it is severe
  • Cold compresses at home

Outlook 

Paediatricians believe while untreated KD can be fatal in 6-8 weeks since the start of the condition, the outlook is favourable for most children. Coronary artery conditions including aneurysms affect only 6% of children being treated for KD. And out of these 6%, nearly 50% of them heal within 1 or 2 years of treatment.

For precise diagnosis and effective treatment of Kawasaki Disease, trust the expertise at Kauvery Hospital. With branches in Chennai, Hosur, Salem, Tirunelveli, and Trichy, we are committed to providing high-quality healthcare for children in a warm and kid-friendly environment. Reach out to us today and ensure your child’s good health and well-being.

What Every Parent Needs to Know About Kawasaki Disease 

What is Kawasaki Disease and who does it affect?
Kawasaki Disease is a rare form of vasculitis that causes inflammation of blood vessels, mostly affecting children under 5 years old.

What are the main symptoms of Kawasaki Disease in children?
Symptoms include persistent fever, red eyes, rashes, swollen hands and feet, cracked lips, and a strawberry tongue. These may be followed by abdominal pain and vomiting.

What causes Kawasaki Disease?
The exact cause is unknown. Experts suspect it could be linked to infections or environmental triggers, but it is not contagious.

Can Kawasaki Disease cause heart problems?
Yes, if not treated early, it can lead to serious heart issues like coronary artery aneurysms, myocarditis, and even heart failure.

How is Kawasaki Disease treated?
Treatment involves intravenous immunoglobulin (IVIG), aspirin, and sometimes steroids or anticoagulants to reduce inflammation and protect the heart.

What is the recovery outlook for Kawasaki Disease?
With early diagnosis and proper treatment, most children recover fully. Ongoing monitoring may be needed if there are heart complications.

 

Kauvery Hospital is globally known for its multidisciplinary services at all its Centers of Excellence, and for its comprehensive, Avant-Grade technology, especially in diagnostics and remedial care in heart diseases, transplantation, vascular and neurosciences medicine. Located in the heart of Trichy (Tennur, Royal Road and Alexandria Road (Cantonment), Chennai (Alwarpet, Vadapalani & Radial Road), Hosur, Salem, Tirunelveli and Bengaluru, the hospital also renders adult and paediatric trauma care.

Chennai Alwarpet – 044 4000 6000 • Chennai Vadapalani – 044 4000 6000 • Chennai Radial Road – 044 40504050 • Trichy – Cantonment – 0431 4077777 • Trichy – Heartcity – 0431 4077777 • Trichy – Tennur – 0431 4022555 • Maa Kauvery Trichy – 0431 4077777 • Kauvery Cancer Institute, Trichy – 0431 4077777 • Hosur – 04344 272727 • Salem – 0427 2677777 • Tirunelveli – 0462 4006000 • Bengaluru – 080 6801 68011