The Risks of Long-term Intermittent Fasting

The Risks of Long-term Intermittent Fasting
February 23 07:22 2026 Print This Article

Summary 

Intermittent fasting (IF) is an eating pattern that focuses on when you eat, rather than what you eat. Instead of spreading meals across a 14-hour window, IF shortens the eating window to encourage longer fasting periods—typically 14–16 hours. This pushes the body to use up glucose and glycogen stores before switching to fat burning, a process known as metabolic switching or ketosis. The most common methods include the 16:8 plan (16 hours fasting, 8 hours eating) and the 5:2 diet (normal eating five days a week, with restricted calories on two non-consecutive days).

Research suggests IF can support weight loss, improve insulin sensitivity, trigger cellular repair processes such as autophagy, and even increase human growth hormone (HGH) levels. Some studies also indicate potential benefits for memory, brain health, and longevity. However, IF is not without drawbacks. Hunger, fatigue, and mood swings are common, while poorly managed fasting can lead to malnutrition, binge eating, or worsen eating disorders. Women may also face hormonal imbalances. Importantly, a large study found that people who restricted eating to less than 8 hours a day had a much higher risk of cardiovascular death compared to those with longer eating windows.

IF may be effective as a short-term weight loss tool, but it is not suitable for everyone. People with chronic conditions, children, teenagers, and those with a history of eating disorders should avoid it. Consulting a family doctor before starting is essential.

What is Intermittent Fasting? 

Intermittent fasting is a dietary schedule that creates an extended fasting window, typically within a 24-hour eating cycle. Unlike most fad diets, intermittent fasting does not focus on what you eat, but on when you eat.

An average, non-fasting adult might have breakfast at 8 am, lunch at 1 pm, an evening snack around 4 pm, dinner at 8 pm, and sometimes dessert or a late-night snack at 10 pm. This creates an eating window of roughly 14 hours (8 am to 10 pm), followed by a fasting window of about 10 hours while asleep.

Intermittent fasting increases the fasting window to about 14–16 hours (sometimes more), pushing the body to exhaust its glucose reserves before switching to burning stored fat. The primary goal is usually fat loss.

Often touted as a “modern metabolism hack”, intermittent fasting is popular among people seeking to lose weight when traditional diet and exercise strategies have not worked. But is it really the magical solution it is claimed to be? Let’s investigate.

How does Intermittent Fasting Work? 

When you fast for long periods, your body first uses the glucose in your blood and glycogen stored in your liver and muscles. Once these reserves are depleted, it begins burning fat for energy. This shift, called metabolic switching, is also known as ketosis.

  • The 16:8 fasting plan is the most common strategy. It gives you an 8-hour eating window where you can eat and drink what you want, followed by a 16-hour fasting window where only non-caloric drinks such as water, black coffee, or unsweetened tea are allowed. Many starts by doing this once or twice a week, eventually adopting it daily if it suits them.
  • The 5:2 diet is another approach, where you eat normally for five days a week and limit intake to about 500–600 calories (roughly 25% of daily needs) on two non-consecutive fasting days. While more flexible, it tends to be less effective since adherence rates are similar to traditional calorie-restriction diets.

Benefits of Intermittent Fasting 

Intermittent fasting is scientifically supported for fat burning and weight reduction. Beyond weight loss, fasting may provide additional health benefits:

  • Insulin sensitivity: Blood insulin levels drop, which lowers blood sugar levels and encourages fat burning. For those with high insulin levels (for example, pre-diabetics), this can help regulate glucose.
  • Cellular repair: During fasting, cells activate autophagy recycling damaged proteins and organelles to create new building blocks and energy. Exercise also triggers this process.
  • Human growth hormone (HGH): IF can significantly increase HGH levels, supporting metabolism, fat burning, and tissue repair.
  • Cognitive function and memory: Some studies suggest IF protects the brain from damage associated with Alzheimer’s, improves memory, and increases brain-derived neurotrophic factor (BDNF), which supports neuron growth.
  • Longevity potential: Early research indicates IF may extend lifespan by reducing inflammation and promoting cellular regeneration, though more human studies are needed.

Drawbacks of Intermittent Fasting 

While promising, IF does not work for everyone, and much supporting research is based on animal studies. Reported drawbacks include:

  • Short-term effects: Headaches, fatigue, mood swings, and sleep disturbances.
  • Malnutrition risk: If poorly managed, fasting can result in nutrient deficiencies.
  • Hunger and cravings: For some, fasting triggers binge eating and weight gain.
  • Disordered eating patterns: IF may mask or worsen eating disorders, and in women, severe restriction can cause hormonal imbalances (such as hair loss or irregular menstruation).
  • Visceral fat resistance: Some studies suggest IF is less effective at reducing visceral belly fat, the very fat many hope to target.

Who Should and Should not Try Intermittent Fasting?

IF is not a universal solution. Medical guidance is essential before starting.

Suitable candidates: Healthy adults without chronic health issues who want to lose weight and can maintain balanced nutrition during fasting.

Not recommended for:

  • Children and teenagers
  • People with eating disorders
  • Women who are pregnant or breastfeeding
  • Individuals with type 2 diabetes, heart disease, or low blood pressure, unless under medical supervision

Is Intermittent Fasting a Good Long-Term Strategy? 

Evidence shows IF can be effective as a short-term strategy (3–6 months). Many people lose weight because the restricted eating window naturally reduces calorie intake.

However, problems arise when IF is practised long term:

  • A large study (2003–2008) tracking over 19,000 adults found that those eating within an 8-hour or shorter window had a 135% higher risk of cardiovascular death compared to people with a 12–14-hour window. This risk was consistent across age, gender, race, and background, and was particularly high among smokers and diabetics.
  • No clear link was found between IF and cancer risk.
  • Many fasters focus only on when to eat, not what to eat leading to nutrient deficiencies. Chronic malnutrition can cause the body to store more fat, countering weight-loss efforts.
  • Intermittent fasting is essentially a form of controlled stress. Under optimal conditions, it may provide benefits, but it can just as easily tip into harm if health, nutrition, or mental state changes.
  • A healthier approach may be to practise IF for a limited period (3–6 months) and then return to a longer eating window, maintaining weight through balanced nutrition and exercise.

Final Word 

The success of intermittent fasting depends heavily on individual health, lifestyle, and psychological factors. For some, it can be an effective short-term tool for weight loss and metabolic health. For others, it may be risky or unsustainable.

Always consult your family doctor before starting IF. It is unlikely to work as a stand-alone weight-loss solution and should ideally be combined with a balanced diet and regular physical activity.

Before adopting intermittent fasting, especially as a long-term strategy, it’s important to assess whether it suits your health and nutritional needs. Kauvery Hospital, with branches in Chennai, Hosur, Salem, Tirunelveli, and Trichy, offers expert medical guidance, metabolic evaluation, and personalized nutrition advice to help you choose safe, sustainable approaches to weight management.

Frequently Asked Questions

Is long-term intermittent fasting safe?

Long-term intermittent fasting is not safe for everyone. While short-term fasting may support weight loss, prolonged fasting may increase the risk of nutrient deficiencies, hormonal imbalance, and heart complications. Medical supervision is strongly recommended.

What are the health risks of practicing intermittent fasting for years?

Possible risks include vitamin and mineral deficiencies, fatigue, menstrual irregularities, binge eating patterns, muscle loss, and increased cardiovascular risk, especially with very short eating windows.

Can intermittent fasting increase heart disease risk?

Some research suggests that restricting eating to less than 8 hours daily may be associated with a higher risk of cardiovascular death. More research is ongoing, but heart health should be monitored carefully.

Does intermittent fasting affect women differently?

Yes. Women may experience hormonal disruptions, irregular periods, hair loss, mood changes, and metabolic stress if fasting is too restrictive or prolonged.

Can intermittent fasting cause nutritional deficiencies?

Yes. If meals during the eating window are not balanced and nutrient-dense, long-term fasting can lead to deficiencies in protein, iron, vitamin B12, calcium, and other essential nutrients.

Is intermittent fasting good for long-term weight loss?

It can help with short-term weight loss. However, long-term success depends on overall diet quality, calorie balance, and lifestyle habits. Many people regain weight if sustainable habits are not developed.

Can intermittent fasting worsen eating disorders?

Yes. Intermittent fasting can trigger unhealthy food restriction cycles, binge eating, or worsen existing eating disorders. It is not recommended for individuals with a history of disordered eating.

Who should avoid intermittent fasting?

Children, teenagers, pregnant or breastfeeding women, people with diabetes, heart disease, low blood pressure, or eating disorders should avoid intermittent fasting unless closely supervised by a doctor.

Does intermittent fasting help reduce belly fat?

Intermittent fasting may reduce overall body fat, but it is not proven to be more effective than traditional calorie-controlled diets in specifically reducing visceral belly fat.

Should I consult a doctor before starting long-term intermittent fasting?

Yes. A medical consultation helps assess metabolic health, medication interactions, and potential risks before beginning or continuing intermittent fasting long term.

Kauvery Hospital is globally known for its multidisciplinary services at all its Centers of Excellence, and for its comprehensive, Avant-Grade technology, especially in diagnostics and remedial care in heart diseases, transplantation, vascular and neurosciences medicine. Located in the heart of Trichy (Tennur, Royal Road and Alexandria Road (Cantonment), Chennai (Alwarpet, Radial Road & Vadapalani), Hosur, Salem, Tirunelveli and Bengaluru, the hospital also renders adult and paediatric trauma care.

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