TMLI Treatment Explained: Meaning, Benefits, and Procedure
What is TMLI?
Total Marrow and Lymphoid Irradiation (TMLI) is an advanced radiation technique used to prepare patients for stem cell or bone marrow transplantation.
Unlike traditional Total Body Irradiation (TBI), which exposes the entire body to radiation, TMLI delivers radiation only to the areas where blood cancers are most likely to be present — the bone marrow and lymphoid tissues. By sparing vital organs such as the lungs, heart, and liver, TMLI makes treatment safer and better tolerated.
Why TMLI Matters
- Precision over blanket exposure – Targets marrow and lymphoid regions while protecting other organs.
- Better tolerated – Patients often experience fewer side effects compared to TBI.
- Optimised for transplant – Creates the right conditions for new donor stem cells to take hold.
- Hope for high-risk patients – Expands treatment possibilities for patients who may not tolerate conventional full-body radiation.
How the TMLI Treatment Works
- Individualised Planning – Advanced imaging is used to map each patient’s marrow and lymphoid tissues.
- Precise Radiation Delivery – Radiation is directed only to those mapped areas, reducing exposure to healthy tissue.
- Transplant Preparation – By eliminating diseased cells in marrow and lymphoid tissues, TMLI makes way for healthy stem cells to grow.
TMLI Treatment Process
Every patient’s journey with TMLI is unique, but the focus is always the same — safety, precision, and comfort.
- Personalised Planning – Before treatment begins, detailed scans are used to design a plan tailored to each patient’s needs.
- Focused Treatment – Radiation is carefully directed only to areas that need it, protecting the rest of the body.
- Ongoing Support – Throughout the process, patients and families are supported not just medically, but also emotionally, by a dedicated team of doctors, nurses, and counsellors.
Safety, Support, and Our Commitment to TMLI Care
Safety and Support
Like all advanced treatments, TMLI can cause side effects, but these are often fewer compared to conventional methods. At Kauvery, patients are closely monitored and supported by a dedicated transplant team – doctors, nurses, and counsellors working together to ensure safety and dignity at every step.
Our Commitment
TMLI represents Kauvery’s effort to bring the latest, safest, and most effective cancer treatments to patients, without losing sight of the human side of care. It is another way we combine precision medicine with compassion.
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‘Frequently Asked Questions about TMLI
TBI radiates the entire body, while TMLI focuses on the marrow and lymphoid tissues, sparing healthy organs
Patients preparing for stem cell or bone marrow transplantation, especially for blood cancers such as leukemia or lymphoma.
Yes. It is planned with advanced imaging and delivered under strict monitoring.
TMLI offers a more precise and patient-friendly way of preparing for transplantation. By protecting vital organs and focusing treatment only where it is needed, it brings new hope and safety to cancer care.
The duration of TMLI can vary based on each patient’s condition. Typically, the treatment is delivered over several sessions spread across a few days to ensure precision and safety while minimizing radiation therapy side effects.
TMLI provides advanced radiation therapy for cancer that is personalized for each patient. By targeting only, the affected marrow and lymphoid areas, it minimizes damage to healthy tissues, lowers side effects, and improves transplant outcomes.
TMLI is part of personalized cancer care because treatment planning is tailored to each patient’s anatomy and disease. Advanced imaging ensures radiation is delivered precisely where it’s needed, protecting healthy organs while maximizing therapeutic benefits.
