Drug induced Hypersensitivity reaction
- A female patient of 27 years was admitted to the hospital for excision of fibroadenoma, breast.
- She was placed on NPO status and prescribed medications, such as Inj.Cefotaxime 1gm STAT,
- Ondansetron, pantoprazole.
- She developed itching, rashes and raised bumps all over the body within seconds of receiving the
- STAT test dose of cefotaxime.
Clinical findings
Diagnosis was made as Drug induced Hypersensitivity reaction.
Cefotaxime, a cephalosporin antibiotic, is known to cause these reactions.
Discussion
- Cefotaxime is a beta-lactam antibiotic classified as a third-generation cephalosporin. Its broad-spectrum antibacterial activity is useful in treating the susceptible strains of bacteria.
- Immediate Hypersensitivity (Type I) reaction involves the release of histamine and other chemicals from mast cells and basophils in response to an allergen.
- It typically occurs within minutes of exposure to the allergen and can lead to symptoms such as hives, itching, nasal congestion, wheezing, and anaphylaxis.
Reference: https://ijppr.humanjournals.com/wp-content/uploads/2022/07/5.Eldhose-Elias-George-Anjali-Shaju-Bony-George.pdf
