A cross-sectional study on the epidemiological data, clinical characteristics, and echocardiographic parameters of pulmonary hypertension patients in a tertiary care centre

P. Manokar

Senior Interventional Cardiologist, Kauvery Hospital, Vadapalani, Chennai

Background and Rationale

Pulmonary hypertension (PH) is a pathophysiological condition characterized by elevated pulmonary artery pressures, resulting in significant morbidity and mortality if untreated. Indian data regarding PH is limited, though global and national registries have provided essential parameters and classifications.

In our setting, PH is primarily diagnosed using echocardiography. A better understanding of epidemiological and clinical profiles will help in timely diagnosis and intervention.

Aims and Objectives

Primary Objective

To study the epidemiological data, clinical characteristics, and echocardiographic parameters and one year follow up of patients with pulmonary hypertension presenting to Kauvery Hospital, Vadapalani.

Methodology

  • Study Design: Cross-sectional observational study
  • Study Period: 1 year (6 months & 12 moths follow up)
  • Study Population: All patients diagnosed with PH based on echocardiographic parameters during the study period.
  • Sample Size: 70 patients (convenience sampling)

Inclusion Criteria

  • Adults (>18 years) diagnosed with pulmonary hypertension by echocardiography
  • Patients willing to provide informed consent

Exclusion Criteria

  • Patients with inadequate echocardiographic data
  • Patients with poor echo window or unconfirmed PH diagnosis

Data Collection

Structured questionnaire and clinical proforma and Echocardiographic parameters as per ESC/ERS guidelines

  • Right atrial size
  • Right ventricle size
  • Right atrial pressure
  • Tricuspid regurgitation jet velocity and pressure gradient
  • Pulmonary regurgitation jet velocity and pressure gradient
  • Pulmonary artery systolic pressure
  • Diastolic pulmonary artery pressure
  • Mean pulmonary artery pressure
  • Pulmonary artery acceleration time
  • Tricuspid Annular Plane Systolic Excursion

Statistical Analysis

The data obtained will be analysed with Microsoft Excel Worksheet and the following statistical methods will be used to arrive at a conclusion:

Observative statistics (frequency tables, mean and standard deviation), comparative analysis, inter quartile range, and tests of significance will be recorded.

Ethical Considerations

  • Informed written consent will be obtained from all participants
  • Confidentiality of patient information will be maintained
  • Study will be conducted as per ICMR guidelines and Declaration of Helsinki
  • Institutional Ethics Committee approval will be obtained prior to initiation

Expected Outcome

Pulmonary hypertension decreases the quality of life of patients and increases re-hospitalization and mortality. Hence, early identification of pulmonary hypertension and institution of guideline directed therapy will improve morbidity and reduce re-hospitalizaton rate.

Kauverian Bookshelf

Applied Medical Statistics

Journals

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